NMN During Menopause: Lisa's Real Story | Genevity+
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There was a point when Lisa almost gave up on feeling like herself again.
She was going through menopause. Her energy was low. She was dealing with depression. Even ordinary days had become difficult.
And if you've ever been through a period where your body doesn't seem to cooperate the way it used to, you'll understand why her story matters.
Then Lisa noticed something curious.
A man she knew appeared to be aging remarkably well. She asked what he was doing differently.
His answer?
NMN.
That conversation led Lisa to discover Genevity+.
She placed her first NMN order in January 2025. And today, she's sharing what happened next.
Watch Lisa's Real NMN Story
Lisa talks openly about menopause, the difficult chapter she went through, and the changes she noticed as NMN became part of her routine.
We think her story is best heard in her own words.
Watch Lisa's story on Instagram →
"It Wasn't Overnight at All."
There's something we really appreciate about how Lisa tells her story.
She doesn't describe a miraculous overnight transformation.
She describes a gradual change in how she felt.
After starting her NMN routine, Lisa says she began noticing things that made a real difference to everyday life.
She talks about having more energy throughout the day, sleeping better, and no longer feeling the same need for afternoon naps.
And then there's the walking.
Lisa now describes going on walks of five or six miles.
For someone who had been struggling through such a difficult period, being able to enjoy those ordinary things again felt significant.
We can't say that NMN caused every improvement she experienced. Menopause, sleep, mental health, lifestyle, and other factors can all influence how someone feels.
But Lisa wanted to share her personal experience. And we're grateful that she did.
Why Are Women Talking About NMN During Menopause?
Menopause can be a strange experience.
For years, you know your body. You know how much energy you normally have, how well you sleep, and what feels comfortable.
Then things start changing.
Some women notice disrupted sleep, changing body composition, or a loss of stamina. Others describe feeling less like themselves, even when they're doing many of the same things they've always done.
And understandably, they start looking for answers.
That's one reason NMN is coming up in conversations about women's health and longevity.
NMN supports the body's production of NAD+, a molecule essential for cellular energy metabolism.
NAD+ is involved in the chemical reactions that help cells convert nutrients into usable energy. It also participates in processes related to normal cellular maintenance and stress responses.
Because NAD+ metabolism changes with age, scientists are interested in whether supporting these pathways can influence aspects of healthy aging.
And importantly, NMN isn't being studied only in men.
Researchers have investigated it in postmenopausal women too.
What Happened When Researchers Studied NMN in Postmenopausal Women?
In 2021, researchers at Washington University School of Medicine published a human clinical trial in the prestigious journal Science.
They studied postmenopausal women who were overweight or obese and had prediabetes.
Over 10 weeks, participants received either 250 mg of NMN daily or a placebo.
Women receiving NMN showed improved skeletal muscle insulin sensitivity.
Researchers also observed improvements in insulin signaling inside the muscle tissue.
That matters because insulin helps your body move glucose from the bloodstream into cells, where it can be used or stored.
Maintaining healthy insulin sensitivity is an important part of metabolic health, particularly as we get older.
And this wasn't just a questionnaire asking women whether they felt better.
The researchers measured changes in their muscles.
The study involved a specific group of women with metabolic risk factors, rather than everyone going through menopause. It didn't test whether NMN relieves hot flashes or depression.
But it offers an encouraging starting point for research into NMN and women's metabolic health.
Source: Yoshino et al., Science, 2021
What Other Women Are Saying About NMN
Lisa isn't the only woman interested in what NMN might mean for life in her 40s, 50s, and beyond.
In online longevity communities, women are asking questions about NMN, menopause, energy, physical activity, and sleep.
For example, in a Reddit discussion titled "For menopause?", a 50-year-old woman talked about noticing stiffness, reduced stamina, and weight gain.
She loved dancing and staying active, and wanted to know whether NMN was worth exploring.
Another woman, aged 51, replied that she'd been taking NMN alongside TMG for around eight months.
She described having good energy, sleeping well, and experiencing a relatively stable mood while going through perimenopause.
That's an individual report, not a clinical trial. And because she was taking both NMN and TMG, we can't attribute her experience to NMN alone.
Still, it's an interesting conversation, and one many women navigating midlife will recognize.
There are also women who report little difference or unwanted changes, which is why individual experiences should be treated as experiences rather than guarantees.
What these discussions show is that women are actively exploring how to support their health as their bodies change.
And NMN is becoming part of that conversation.
Beyond Menopause: What Other Human NMN Studies Have Found
One of the most exciting things about NMN is that research is moving beyond theory.
Scientists have now studied NMN in human clinical trials, looking at everything from NAD+ levels to physical performance.
1. NMN increased NAD+ levels in a human trial
In a 2022 randomized clinical trial, healthy adults took 250 mg of NMN daily for 12 weeks.
The researchers found that NMN significantly increased NAD+ levels in whole blood compared with placebo.
That's important because NAD+ production is the central biological reason people take NMN.
Here, researchers demonstrated that oral supplementation could increase a measurable NAD+ marker in humans.
Source: Okabe et al., Frontiers in Nutrition, 2022
2. Researchers have studied physical function and everyday alertness
Another randomized clinical trial, published in 2022, followed 108 older adults for 12 weeks.
Researchers investigated sleep, fatigue, drowsiness, and physical performance.
The group taking NMN in the afternoon showed encouraging results for daytime drowsiness and a lower-body physical performance test.
Other study groups also improved on some measures, so the findings aren't a promise that everyone will feel more energetic.
But it's encouraging to see scientists investigating outcomes that actually matter in daily life.
Source: Kim et al., Nutrients, 2022
3. A 2026 review found encouraging evidence for endurance and quality of life
More recently, a systematic review and network meta-analysis published in 2026 examined 27 studies involving 1,599 participants.
Researchers compared several NAD+ precursors, including NMN, across measures of physical performance, fatigue, sleep, and quality of life.
NMN showed promising results for endurance-related performance, particularly in the medium- and higher-dose groups studied.
The researchers also identified improvements in quality-of-life measures in some NMN groups.
That's an interesting development because endurance, mobility, and quality of life are important parts of healthy aging.
The review didn't find consistent improvements in subjective fatigue or sleep, so these outcomes remain areas for further investigation.
Source: Systematic review and network meta-analysis, 2026
Why Some People Take NMN Alongside TMG
If you've been researching NMN, you've probably seen TMG mentioned too.
TMG stands for trimethylglycine, also known as betaine.
It's a naturally occurring compound that helps supply methyl groups, which your body uses in processes such as homocysteine metabolism.
That makes TMG relevant to discussions about methylation, one of the body's normal biochemical processes.
Some longevity enthusiasts choose to include both NMN and TMG in their routines because the two compounds participate in different metabolic pathways.
It's useful to understand the distinction.
NMN is a precursor to NAD+.
TMG supports normal methylation processes.
TMG isn't required for NMN to work, and clinical research hasn't established that adding TMG improves NMN's effects.
But for people interested in both NAD+ metabolism and methylation support, they're two supplements worth learning about.
Maybe Lisa's Story Feels Familiar
Perhaps you're going through menopause yourself.
Maybe you've noticed your energy isn't what it used to be. Or perhaps you're simply becoming more interested in what you can do now to support your health over the coming years.
There isn't one supplement that can solve every problem associated with aging.
But there are worthwhile decisions you can make.
Staying active. Looking after your sleep. Eating well. Getting medical support when you need it.
And learning about the biological processes that help keep your body functioning.
For people interested in NAD+ metabolism, NMN is one option to explore.
Lisa decided to explore it in January 2025.
Her experience won't necessarily be yours.
But perhaps her story will encourage you to start paying a little more attention to your own health.
That alone can be the beginning of something worthwhile.
Interested in Trying Genevity+ NMN?
If you've been curious about NMN but haven't known where to start, we're here to make the decision easier.
Genevity+ offers NMN in two forms:
- NMN Lipo capsules for a simple, pre-measured daily routine.
- NMN Powder for people who prefer flexibility in how they measure their serving.
Both provide NMN, a precursor your body uses to make NAD+.
You can also explore TMG as a separate part of your supplement routine if methylation support is one of your goals.
Start by choosing the NMN format that best fits your routine and reviewing the product information.
Thank You, Lisa 🩵
Lisa, we want to finish by saying thank you.
Thank you for trusting us with such a personal part of your life.
For speaking openly about the difficult days, the changes you've noticed, and what this journey has meant to you.
It's easy for a supplement company to spend all day talking about molecules, studies, and ingredients.
But people like Lisa remind us why those conversations matter.
We wish you many more beautiful walks and happy days ahead.
With love from the Genevity+ team. 🩵
Frequently Asked Questions
Can NMN help with menopause?
NMN has been studied in postmenopausal women, with one clinical trial reporting improvements in skeletal muscle insulin sensitivity in women with prediabetes. Some women also describe positive personal experiences with NMN during menopause. However, NMN has not been clinically established as a treatment for menopause symptoms.
Does NMN increase NAD+ levels?
Human clinical studies have shown that oral NMN supplementation can increase NAD+ levels measured in blood. NAD+ is an essential molecule involved in cellular energy metabolism and other normal cellular processes.
How long does NMN take to work?
Human studies have measured changes in NAD+ levels and other outcomes over periods of several weeks. How someone feels, and whether they notice a change at all, varies. Lisa describes her personal experience as gradual rather than immediate.
Can I take NMN with TMG?
Some people include NMN and TMG in the same supplement routine. NMN is a precursor to NAD+, while TMG participates in normal methylation processes. TMG is not proven to be necessary for NMN supplementation. Consult a healthcare professional if you're unsure whether either supplement is suitable for you.
Is NMN suitable for women over 40 or 50?
NMN has been investigated in middle-aged and older adults, including postmenopausal women. Suitability depends on individual health circumstances and medications. Women experiencing persistent menopausal symptoms should seek appropriate medical advice rather than relying on supplements alone.
Important: This article includes individual customer experiences, public community discussions, and findings from clinical research. Personal stories do not establish typical results or prove that NMN caused the changes described. NMN is not an established treatment for menopause, depression, or other medical conditions. Consult your healthcare professional before beginning a new supplement, particularly if you have health conditions or take medication.
